Multi-Dose Priming Regimens of PfSPZ Vaccine: Safety and Efficacy against Controlled Human Malaria Infection in Equatoguinean Adults

Plasmodium falciparum sporozoite (PfSPZ) Vaccine is composed of radiation-attenuated, aseptic, purified cryopreserved PfSPZ. Multiple clinical trials empirically assessing two to six doses have shown multi-dose priming (two to four doses the first week) to be optimal for protection in both 4- and 16...

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Autores principales: Jongo, Said Abdallah, Church, L. W. Preston, Nchama, Vicente Urbano Nsue Ndong, Hamad, Ali, Chuquiyauri, Raul, Kassim, Kamaka Ramadhani, Athuman, Thabit, Deal, Anna, Natasha, KC, Mtoro, Ali, Mpina, Maxmillian, Nyakarungu, Elizabeth, Bidjimi, Gertrudis Owono, Owono, Marta Alene, Mayé, Escolástica Raquel Mansogo, Mangue, Martín Eká Ondó, Okomo, Genaro Nsué Nguema, Pasialo, Beltrán Ekuá Ntutumu, Mandumbi, Dolores Mbang Ondó, Mikue, María-Silvia A. López, Mochomuemue, Fortunata Lobede, Obono, Mariano Obiang, Besahá, Juan Carlos Momo, Bijeri, José Raso, Abegue, Gabriel Mbá, Veri, Yolanda Rimoy, Bela, Ines Toichoa, Chochi, Federico Comsil, Lima Sánchez, José Enrique, Pencelli, Vanessa, Gayozo, Griselda, Nlang, José Antonio Esono Mbá, Schindler, Tobias, James, Eric R., Abebe, Yonas, Lemiale, Laurence, Stabler, Thomas C., Murshedkar, Tooba, Chen, Mei-Chun, Schwabe, Christopher, Ratsirarson, Josea, Rivas, Matilde Riloha, Ayekaba, Mitoha Ondo’o, Milang, Diosdado Vicente Nsué, Falla, Carlos Cortés, Phiri, Wonder P., García, Guillermo A., Maas, Carl D., Nlavo, Bonifacio Manguire, Tanner, Marcel, Billingsley, Peter F., Kim Lee Sim, B., Daubenberger, Claudia, Hoffman, Stephen L., Abdulla, Salim, Richie, Thomas L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991366/
https://www.ncbi.nlm.nih.gov/pubmed/35130487
http://dx.doi.org/10.4269/ajtmh.21-0942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991366/
https://www.ncbi.nlm.nih.gov/pubmed/35130487
http://dx.doi.org/10.4269/ajtmh.21-0942

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