Pharmacokinetics of ß-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection

ß-d-N4-hydroxycytidine (NHC), the parent nucleoside of molnupiravir, a COVID-19 antiviral, was quantified at SARS-CoV-2 transmission sites in 12 patients enrolled in AGILE Candidate-Specific Trial-2. Saliva, nasal, and tear NHC concentrations were 3%, 21%, and 22% that of plasma. Saliva and nasal NH...

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Detalles Bibliográficos
Autores principales: FitzGerald, Richard, Dickinson, Laura, Else, Laura, Fletcher, Thomas, Hale, Colin, Amara, Alieu, Walker, Lauren, Penchala, Sujan Dilly, Lyon, Rebecca, Shaw, Victoria, Greenhalf, William, Bullock, Katie, Lavelle-Langham, Lara, Reynolds, Helen, Painter, Wendy, Holman, Wayne, Ewings, Sean, Griffiths, Gareth, Khoo, Saye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992239/
https://www.ncbi.nlm.nih.gov/pubmed/35271729
http://dx.doi.org/10.1093/cid/ciac199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992239/
https://www.ncbi.nlm.nih.gov/pubmed/35271729
http://dx.doi.org/10.1093/cid/ciac199

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