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Pharmacokinetics of ß-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection
ß-d-N4-hydroxycytidine (NHC), the parent nucleoside of molnupiravir, a COVID-19 antiviral, was quantified at SARS-CoV-2 transmission sites in 12 patients enrolled in AGILE Candidate-Specific Trial-2. Saliva, nasal, and tear NHC concentrations were 3%, 21%, and 22% that of plasma. Saliva and nasal NH...
| Autores principales: | , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992239/ https://www.ncbi.nlm.nih.gov/pubmed/35271729 http://dx.doi.org/10.1093/cid/ciac199 |
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| author | FitzGerald, Richard Dickinson, Laura Else, Laura Fletcher, Thomas Hale, Colin Amara, Alieu Walker, Lauren Penchala, Sujan Dilly Lyon, Rebecca Shaw, Victoria Greenhalf, William Bullock, Katie Lavelle-Langham, Lara Reynolds, Helen Painter, Wendy Holman, Wayne Ewings, Sean Griffiths, Gareth Khoo, Saye |
| author_facet | FitzGerald, Richard Dickinson, Laura Else, Laura Fletcher, Thomas Hale, Colin Amara, Alieu Walker, Lauren Penchala, Sujan Dilly Lyon, Rebecca Shaw, Victoria Greenhalf, William Bullock, Katie Lavelle-Langham, Lara Reynolds, Helen Painter, Wendy Holman, Wayne Ewings, Sean Griffiths, Gareth Khoo, Saye |
| author_sort | FitzGerald, Richard |
| collection | PubMed |
| description | ß-d-N4-hydroxycytidine (NHC), the parent nucleoside of molnupiravir, a COVID-19 antiviral, was quantified at SARS-CoV-2 transmission sites in 12 patients enrolled in AGILE Candidate-Specific Trial-2. Saliva, nasal, and tear NHC concentrations were 3%, 21%, and 22% that of plasma. Saliva and nasal NHC were significantly correlated with plasma (P < .0001). Clinical Trials Registration. NCT04746183. |
| format | Online Article Text |
| id | pubmed-8992239 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-89922392022-04-12 Pharmacokinetics of ß-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection FitzGerald, Richard Dickinson, Laura Else, Laura Fletcher, Thomas Hale, Colin Amara, Alieu Walker, Lauren Penchala, Sujan Dilly Lyon, Rebecca Shaw, Victoria Greenhalf, William Bullock, Katie Lavelle-Langham, Lara Reynolds, Helen Painter, Wendy Holman, Wayne Ewings, Sean Griffiths, Gareth Khoo, Saye Clin Infect Dis Brief Report ß-d-N4-hydroxycytidine (NHC), the parent nucleoside of molnupiravir, a COVID-19 antiviral, was quantified at SARS-CoV-2 transmission sites in 12 patients enrolled in AGILE Candidate-Specific Trial-2. Saliva, nasal, and tear NHC concentrations were 3%, 21%, and 22% that of plasma. Saliva and nasal NHC were significantly correlated with plasma (P < .0001). Clinical Trials Registration. NCT04746183. Oxford University Press 2022-03-10 /pmc/articles/PMC8992239/ /pubmed/35271729 http://dx.doi.org/10.1093/cid/ciac199 Text en © The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Brief Report FitzGerald, Richard Dickinson, Laura Else, Laura Fletcher, Thomas Hale, Colin Amara, Alieu Walker, Lauren Penchala, Sujan Dilly Lyon, Rebecca Shaw, Victoria Greenhalf, William Bullock, Katie Lavelle-Langham, Lara Reynolds, Helen Painter, Wendy Holman, Wayne Ewings, Sean Griffiths, Gareth Khoo, Saye Pharmacokinetics of ß-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection |
| title | Pharmacokinetics of ß-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection |
| title_full | Pharmacokinetics of ß-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection |
| title_fullStr | Pharmacokinetics of ß-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection |
| title_full_unstemmed | Pharmacokinetics of ß-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection |
| title_short | Pharmacokinetics of ß-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection |
| title_sort | pharmacokinetics of ß-d-n4-hydroxycytidine, the parent nucleoside of prodrug molnupiravir, in nonplasma compartments of patients with severe acute respiratory syndrome coronavirus 2 infection |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992239/ https://www.ncbi.nlm.nih.gov/pubmed/35271729 http://dx.doi.org/10.1093/cid/ciac199 |
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