SF3B1 modulators affect key genes in metastasis and drug influx: a new approach to fight pancreatic cancer chemoresistance

Aim: Because mutations of splicing factor 3B subunit-1 (SF3B1) have been identified in 4% of pancreatic ductal adenocarcinoma (PDAC) patients, we investigated the activity of new potential inhibitors of SF3B1 in combination with gemcitabine, one of the standard drugs, in PDAC cell lines. Methods: On...

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Detalles Bibliográficos
Autores principales: Randazzo, Ornella, Cascioferro, Stella M., Pecoraro, Camilla, Iddouch, Widad Ait, Avan, Amir, Parrino, Barbara, Carbone, Daniela, Perricone, Ugo, Peters, Godefridus J., Diana, Patrizia, Giovannetti, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OAE Publishing Inc. 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992438/
https://www.ncbi.nlm.nih.gov/pubmed/35582381
http://dx.doi.org/10.20517/cdr.2021.61

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992438/
https://www.ncbi.nlm.nih.gov/pubmed/35582381
http://dx.doi.org/10.20517/cdr.2021.61

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