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Innate and adaptive resistance mechanisms to arginine deprivation therapies in sarcoma and other cancers
Many cancers lack functional expression of the enzyme argininosuccinate synthetase 1 (ASS1) that is necessary for synthesis of L-arginine. These cancers must import arginine for survival and growth, and this reliance can be targeted by arginine-degrading extracellular enzymatic drugs, most commonly...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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OAE Publishing Inc.
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992531/ https://www.ncbi.nlm.nih.gov/pubmed/35582579 http://dx.doi.org/10.20517/cdr.2019.49 |