Early SRC activation skews cell fate from apoptosis to senescence

Cells responding to DNA damage implement complex adaptive programs that often culminate in one of two distinct outcomes: apoptosis or senescence. To systematically identify factors driving each response, we analyzed human IMR-90 fibroblasts exposed to increasing doses of the genotoxin etoposide and...

Descripción completa

Detalles Bibliográficos
Autores principales: Anerillas, Carlos, Herman, Allison B., Rossi, Martina, Munk, Rachel, Lehrmann, Elin, Martindale, Jennifer L., Cui, Chang-Yi, Abdelmohsen, Kotb, De, Supriyo, Gorospe, Myriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993123/
https://www.ncbi.nlm.nih.gov/pubmed/35394839
http://dx.doi.org/10.1126/sciadv.abm0756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993123/
https://www.ncbi.nlm.nih.gov/pubmed/35394839
http://dx.doi.org/10.1126/sciadv.abm0756

Ejemplares similares