Selinexor in combination with carboplatin and paclitaxel in patients with advanced solid tumors: Results of a single-center, multi-arm phase Ib study

Background. Carboplatin and paclitaxel (CT) is one of the standard chemotherapy regimens used in various tumor types. Preclinical models have suggested that selinexor, a first-in-class oral potent selective inhibitor of nuclear export Exportin-1, and CT exerts antitumor activity in multiple malignan...

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Detalles Bibliográficos
Autores principales: Thein, Kyaw Z., Karp, Daniel D., Tsimberidou, Apostolia, Gong, Jing, Sulovic, Selma, Shah, Jatin, Milton, Denái R., Hong, David S., Janku, Filip, McQuinn, Lacey, Stephen, Bettzy A., Colen, Rivka, Carter, Brett W., Yap, Timothy A., Piha-Paul, Sarina A., Fu, Siqing, Meric-Bernstam, Funda, Naing, Aung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Phase I Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993773/
https://www.ncbi.nlm.nih.gov/pubmed/34562230
http://dx.doi.org/10.1007/s10637-021-01188-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993773/
https://www.ncbi.nlm.nih.gov/pubmed/34562230
http://dx.doi.org/10.1007/s10637-021-01188-1

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