Ischemia-induced cleavage of OPA1 at S1 site aggravates mitochondrial fragmentation and reperfusion injury in neurons

Neuronal mitochondrial dynamics are disturbed after ischemic stroke. Optic atrophy 1 (OPA1) and its GTPase activity are involved in maintaining mitochondrial cristae and inner membrane fusion. This study aimed to explore the role of OMA1-mediated OPA1 cleavage (S1-OPA1) in neurons exposed to cerebra...

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Detalles Bibliográficos
Autores principales: Li, Xiang, Li, Haiying, Xu, Zhongmou, Ma, Cheng, Wang, Tianyi, You, Wanchun, Yu, Zhengquan, Shen, Haitao, Chen, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993832/
https://www.ncbi.nlm.nih.gov/pubmed/35395832
http://dx.doi.org/10.1038/s41419-022-04782-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993832/
https://www.ncbi.nlm.nih.gov/pubmed/35395832
http://dx.doi.org/10.1038/s41419-022-04782-0

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