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Angiotensin II related glial cell activation and necroptosis of retinal ganglion cells after systemic hypotension in glaucoma

The purpose of this study was to design an animal model mimicking glaucoma with hemodynamic instability and to identify involvement of angiotensin II (AngII) and associated changes of the retina. Systemic hypotension was induced in Sprague–Dawley rats by oral hydrochlorothiazide administration. Rats...

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Detalles Bibliográficos
Autores principales: Jeon, Soo Ji, Huh, Jungbin, Jeong, Eojin, Park, Chan Kee, Park, Hae Young Lopilly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993868/
https://www.ncbi.nlm.nih.gov/pubmed/35396550
http://dx.doi.org/10.1038/s41419-022-04762-4