HucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis

Activated hepatic stellate cells (HSCs) are significant in liver fibrosis. Our past investigations have shown that human umbilical cord mesenchymal stem cells (hucMSCs) and their secreted exosomes (MSC-ex) could alleviate liver fibrosis via restraining HSCs activation. However, the mechanisms underl...

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Detalles Bibliográficos
Autores principales: Tan, Youwen, Huang, Yan, Mei, Rong, Mao, Fei, Yang, Dakai, Liu, Jinwen, Xu, Wenrong, Qian, Hui, Yan, Yongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993870/
https://www.ncbi.nlm.nih.gov/pubmed/35395830
http://dx.doi.org/10.1038/s41419-022-04764-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993870/
https://www.ncbi.nlm.nih.gov/pubmed/35395830
http://dx.doi.org/10.1038/s41419-022-04764-2

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