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HucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis

Activated hepatic stellate cells (HSCs) are significant in liver fibrosis. Our past investigations have shown that human umbilical cord mesenchymal stem cells (hucMSCs) and their secreted exosomes (MSC-ex) could alleviate liver fibrosis via restraining HSCs activation. However, the mechanisms underl...

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Detalles Bibliográficos
Autores principales:	Tan, Youwen, Huang, Yan, Mei, Rong, Mao, Fei, Yang, Dakai, Liu, Jinwen, Xu, Wenrong, Qian, Hui, Yan, Yongmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993870/ https://www.ncbi.nlm.nih.gov/pubmed/35395830 http://dx.doi.org/10.1038/s41419-022-04764-2

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