Functional control of a 0.5 MDa TET aminopeptidase by a flexible loop revealed by MAS NMR

Large oligomeric enzymes control a myriad of cellular processes, from protein synthesis and degradation to metabolism. The 0.5 MDa large TET2 aminopeptidase, a prototypical protease important for cellular homeostasis, degrades peptides within a ca. 60 Å wide tetrahedral chamber with four lateral ope...

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Detalles Bibliográficos
Autores principales: Gauto, Diego F., Macek, Pavel, Malinverni, Duccio, Fraga, Hugo, Paloni, Matteo, Sučec, Iva, Hessel, Audrey, Bustamante, Juan Pablo, Barducci, Alessandro, Schanda, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993905/
https://www.ncbi.nlm.nih.gov/pubmed/35395851
http://dx.doi.org/10.1038/s41467-022-29423-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993905/
https://www.ncbi.nlm.nih.gov/pubmed/35395851
http://dx.doi.org/10.1038/s41467-022-29423-0

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