One-pot biosynthesis of 7β-hydroxyandrost-4-ene-3,17-dione from phytosterols by cofactor regeneration system in engineered mycolicibacterium neoaurum

BACKGROUND: 7β-hydroxylated steroids (7β-OHSt) possess significant activities in anti-inflammatory and neuroprotection, and some of them have been widely used in clinics. However, the production of 7β-OHSt is still a challenge due to the lack of cheap 7β-hydroxy precursor and the difficulty in regio...

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Detalles Bibliográficos
Autores principales: Zhao, Yun-Qiu, Liu, Yong-Jun, Ji, Wei-Ting, Liu, Kun, Gao, Bei, Tao, Xin-Yi, Zhao, Ming, Wang, Feng-Qing, Wei, Dong-Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994266/
https://www.ncbi.nlm.nih.gov/pubmed/35397581
http://dx.doi.org/10.1186/s12934-022-01786-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994266/
https://www.ncbi.nlm.nih.gov/pubmed/35397581
http://dx.doi.org/10.1186/s12934-022-01786-5

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