A proteolysis-targeting chimera molecule selectively degrades ENL and inhibits malignant gene expression and tumor growth

BACKGROUND: Chromosome translocations involving mixed lineage leukemia 1 (MLL1) cause acute leukemia in most infants and 5–10% children/adults with dismal clinical outcomes. Most frequent MLL1-fusion partners AF4/AFF4, AF9/ENL and ELL, together with CDK9/cyclin-T1, constitute super elongation comple...

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Detalles Bibliográficos
Autores principales: Li, Xin, Yao, Yuan, Wu, Fangrui, Song, Yongcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994274/
https://www.ncbi.nlm.nih.gov/pubmed/35395864
http://dx.doi.org/10.1186/s13045-022-01258-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994274/
https://www.ncbi.nlm.nih.gov/pubmed/35395864
http://dx.doi.org/10.1186/s13045-022-01258-8

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