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A proteolysis-targeting chimera molecule selectively degrades ENL and inhibits malignant gene expression and tumor growth

BACKGROUND: Chromosome translocations involving mixed lineage leukemia 1 (MLL1) cause acute leukemia in most infants and 5–10% children/adults with dismal clinical outcomes. Most frequent MLL1-fusion partners AF4/AFF4, AF9/ENL and ELL, together with CDK9/cyclin-T1, constitute super elongation comple...

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Detalles Bibliográficos
Autores principales:	Li, Xin, Yao, Yuan, Wu, Fangrui, Song, Yongcheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994274/ https://www.ncbi.nlm.nih.gov/pubmed/35395864 http://dx.doi.org/10.1186/s13045-022-01258-8

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