CRISPR-mediated Bmpr2 point mutation exacerbates late pulmonary vasculopathy and reduces survival in rats with experimental pulmonary hypertension

BACKGROUND: Patients with pulmonary arterial hypertension (PAH) carrying bone morphogenetic protein receptor type 2 (Bmpr2) mutations present earlier with severe hemodynamic compromise and have poorer survival outcomes than those without mutation. The mechanism underlying the worsening clinical phen...

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Detalles Bibliográficos
Autores principales: Kabwe, Jane Chanda, Sawada, Hirofumi, Mitani, Yoshihide, Oshita, Hironori, Tsuboya, Naoki, Zhang, Erquan, Maruyama, Junko, Miyasaka, Yoshiki, Ko, Hideyoshi, Oya, Kazunobu, Ito, Hiromasa, Yodoya, Noriko, Otsuki, Shoichiro, Ohashi, Hiroyuki, Okamoto, Ryuji, Dohi, Kaoru, Nishimura, Yuhei, Mashimo, Tomoji, Hirayama, Masahiro, Maruyama, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994407/
https://www.ncbi.nlm.nih.gov/pubmed/35395852
http://dx.doi.org/10.1186/s12931-022-02005-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994407/
https://www.ncbi.nlm.nih.gov/pubmed/35395852
http://dx.doi.org/10.1186/s12931-022-02005-w

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