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Cdc48 influence on separase levels is independent of mitosis and suggests translational sensitivity of separase

Cdc48 (p97/VCP) is a AAA-ATPase that can extract ubiquitinated proteins from their binding partners and can cooperate with the proteasome for their degradation. A fission yeast cdc48 mutant (cdc48-353) shows low levels of the cohesin protease, separase, and pronounced chromosome segregation defects...

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Detalles Bibliográficos
Autores principales: Vijayakumari, Drisya, Müller, Janina, Hauf, Silke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995007/
https://www.ncbi.nlm.nih.gov/pubmed/35320724
http://dx.doi.org/10.1016/j.celrep.2022.110554