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Cdc48 influence on separase levels is independent of mitosis and suggests translational sensitivity of separase
Cdc48 (p97/VCP) is a AAA-ATPase that can extract ubiquitinated proteins from their binding partners and can cooperate with the proteasome for their degradation. A fission yeast cdc48 mutant (cdc48-353) shows low levels of the cohesin protease, separase, and pronounced chromosome segregation defects...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995007/ https://www.ncbi.nlm.nih.gov/pubmed/35320724 http://dx.doi.org/10.1016/j.celrep.2022.110554 |