Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues

SARS-CoV-2 primarily replicates in mucosal sites, and more information is needed about immune responses in infected tissues. Here, we used rhesus macaques to model protective primary immune responses in tissues during mild COVID-19. Viral RNA levels were highest on days 1-2 post-infection and fell p...

Descripción completa

Detalles Bibliográficos
Autores principales: Nelson, Christine E., Namasivayam, Sivaranjani, Foreman, Taylor W., Kauffman, Keith D., Sakai, Shunsuke, Dorosky, Danielle E., Lora, Nickiana E., Brooks, Kelsie, Potter, E. Lake, Garza, Nicole L., Lafont, Bernard A. P., Johnson, Reed F., Roederer, Mario, Sher, Alan, Weiskopf, Daniela, Sette, Alessandro, de Wit, Emmie, Hickman, Heather D., Brenchley, Jason M., Via, Laura E., Barber, Daniel L., Abdi, Ayan, Dayao, Emmuanual K., Fleegle, Joel D., Gomez, Felipe, Piazza, Michaela K., Repoli, Katelyn M., Sloan, Becky Y., Butler, Ashley L., Walker, April M., Weiner, Danielle M., Woodcock, Michael J., Vatthauer, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995035/
https://www.ncbi.nlm.nih.gov/pubmed/35271298
http://dx.doi.org/10.1126/sciimmunol.abo0535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995035/
https://www.ncbi.nlm.nih.gov/pubmed/35271298
http://dx.doi.org/10.1126/sciimmunol.abo0535

Ejemplares similares