Cargando…

Pharmacological modulation of prostaglandin E(2) (PGE(2)) EP receptors improves cardiomyocyte function under hyperglycemic conditions

Type 2 diabetes (T2D) affects >30 million Americans and nearly 70% of individuals with T2D will die from cardiovascular disease (CVD). Circulating levels of the inflammatory signaling lipid, prostaglandin E(2) (PGE(2)), are elevated in the setting of obesity and T2D and are associated with decrea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bosma, Karin J., Ghosh, Monica, Andrei, Spencer R., Zhong, Lin, Dunn, Jennifer C., Ricciardi, Valerie F., Burkett, Juliann B., Hatzopoulos, Antonis K., Damron, Derek S., Gannon, Maureen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995713/ https://www.ncbi.nlm.nih.gov/pubmed/35403369 http://dx.doi.org/10.14814/phy2.15212

Ejemplares similares

Changing prostaglandin E2 (PGE(2)) signaling during lesional progression and exacerbation of endometriosis by inhibition of PGE(2) receptor EP2 and EP4
por: Huang, Qingqing, et al.
Publicado: (2021)

Pharmacological blockade of the EP3 prostaglandin E(2) receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage
por: Bosma, Karin J., et al.
Publicado: (2021)

Opposing effects of prostaglandin E(2) receptors EP3 and EP4 on mouse and human β-cell survival and proliferation
por: Carboneau, Bethany A., et al.
Publicado: (2017)

A prostaglandin E (PGE) receptor EP4 antagonist protects natural killer cells from PGE(2)-mediated immunosuppression and inhibits breast cancer metastasis
por: Ma, Xinrong, et al.
Publicado: (2013)

COX-2-PGE(2)-EPs in gynecological cancers
por: Ye, Yao, et al.
Publicado: (2020)

Mammalian oocytes are targets for prostaglandin E2 (PGE2) action
por: Duffy, Diane M, et al.
Publicado: (2010)

Prostaglandin E2 (PGE2) and Roflumilast Involvement in IPF Progression
por: Moshkovitz, Noa, et al.
Publicado: (2023)

Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer
por: Ke, Jieqi, et al.
Publicado: (2016)

Role of the PGE(2) receptor subtypes EP1, EP2, and EP3 in repetitive traumatic brain injury
por: Catlin, James, et al.
Publicado: (2019)

15‐Hydroperoxy‐PGE(2): Intermediate in Mammalian and Algal Prostaglandin Biosynthesis
por: Jagusch, Hans, et al.
Publicado: (2019)

Disruption of Epithelium Integrity by Inflammation-Associated Fibroblasts through Prostaglandin Signaling: IAFs disrupt colon epithelium via PGE2-EP4
por: Dong, Yi, et al.
Publicado: (2023)

Tailored PGE2 Immunomodulation of moDCs by Nano-Encapsulated EP2/EP4 Antagonists
por: Bödder, Johanna, et al.
Publicado: (2023)

The Wae to repair: prostaglandin E2 (PGE(2)) triggers intestinal wound repair
por: Jackstadt, Rene, et al.
Publicado: (2017)

PGE2-EP2/EP4 signaling elicits mesoCAR T cell immunosuppression in pancreatic cancer
por: Akbari, Behnia, et al.
Publicado: (2023)

Contribution of PGE(2) EP1 receptor in hemin-induced neurotoxicity
por: Mohan, Shekher, et al.
Publicado: (2013)

Stimulation of TRPA1 attenuates ischemia-induced cardiomyocyte cell death through an eNOS-mediated mechanism
por: Andrei, Spencer R., et al.
Publicado: (2019)

Prostaglandin E(2) (PGE(2)) Exerts Biphasic Effects on Human Tendon Stem Cells
por: Zhang, Jianying, et al.
Publicado: (2014)

Proneoplastic effects of PGE(2 )mediated by EP4 receptor in colorectal cancer
por: Doherty, Glen A, et al.
Publicado: (2009)

The role of PGE(2) EP(4) receptors in the regulation of endothelial barrier function
por: Kampitsch, Nora, et al.
Publicado: (2012)

Effect of selective inhibition or activation of PGE2 EP1 receptor on glomerulosclerosis
por: Chen, Xu, et al.
Publicado: (2020)

PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis
por: Jiang, Wenhao, et al.
Publicado: (2022)

Cloning and expression of the rabbit prostaglandin EP2 receptor
por: Guan, Youfei, et al.
Publicado: (2002)

α-Ketoheterocycles Able to Inhibit the Generation of Prostaglandin E(2) (PGE(2)) in Rat Mesangial Cells
por: Psarra, Anastasia, et al.
Publicado: (2021)

The PGE(2 )EP2 receptor and its selective activation are beneficial against ischemic stroke
por: Ahmad, Muzamil, et al.
Publicado: (2010)

An Update of Microsomal Prostaglandin E Synthase-1 and PGE(2) Receptors in Cardiovascular Health and Diseases
por: Yang, Guangrui, et al.
Publicado: (2016)

Role of EP(2) and EP(4) receptors in airway microvascular leak induced by prostaglandin E(2)
por: Jones, Victoria C, et al.
Publicado: (2016)

Anti-inflammatory effects of PGE(2) in the lung: role of the EP(4) receptor subtype
por: Birrell, Mark A, et al.
Publicado: (2015)

Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE(2)/EP2 signaling
por: Medeiros, Alexandra I., et al.
Publicado: (2009)

PGE2 inhibits neutrophil phagocytosis through the EP2R–cAMP–PTEN pathway
por: Wang, Zixuan, et al.
Publicado: (2022)

The pulmonary microvascular endothelial barrier function is controlled by the PGE(2)-EP(4) signaling axis
por: Kónya, Viktória, et al.
Publicado: (2010)

Intracerebral hemorrhage outcomes following selective blockade or stimulation of the PGE(2) EP1 receptor
por: Leclerc, Jenna L, et al.
Publicado: (2015)

Effect of PGE(2)-EP(s) pathway on primary cultured rat neuron injury caused by aluminum
por: Yang, Lu, et al.
Publicado: (2017)

Heterodimerization of the prostaglandin E2 receptor EP2 and the calcitonin receptor CTR
por: Matsubara, Shin, et al.
Publicado: (2017)

The role of the EP receptors for prostaglandin E(2) in skin and skin cancer
por: Rundhaug, J. E., et al.
Publicado: (2011)

Prostaglandin E2/EP Signaling in the Tumor Microenvironment of Colorectal Cancer
por: Mizuno, Rei, et al.
Publicado: (2019)

Prostaglandin E2 receptor EP1 expression in vulvar cancer
por: Buchholz, Anna, et al.
Publicado: (2022)

Prostaglandin E2 promotes human CD34(+) cells homing through EP2 and EP4 in vitro
por: Wang, Yaqun, et al.
Publicado: (2017)

Concerted EP2 and EP4 Receptor Signaling Stimulates Autocrine Prostaglandin E(2) Activation in Human Podocytes
por: Mangelsen, Eva, et al.
Publicado: (2020)

Characterization of the Signaling Modalities of Prostaglandin E2 Receptors EP2 and EP4 Reveals Crosstalk and a Role for Microtubules
por: Vleeshouwers, Ward, et al.
Publicado: (2021)

The role of prostaglandin E(2 )(PGE (2)) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia
por: Hernandez, Yasmin, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_ulbble56j4oren2opuot7f2tou