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Long‐term low dose nitisinone therapy in adults with alkaptonuria shows no cognitive decline or increased severity of depression

Little is documented on whether nitisinone‐induced hypertyrosinaemia alters cognitive functioning or leads to worsening depression in alkaptonuria (AKU). Wechsler Adult Intelligence Scale‐IV (WAIS‐IV) and Beck Depression Inventory‐II (BDI‐II) assessments were performed before and annually following...

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Detalles Bibliográficos
Autores principales: Davison, Andrew S., Hughes, Gin, Harrold, Joanne A., Clarke, Pam, Griffin, Rebecca, Ranganath, Lakshminarayan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995840/
https://www.ncbi.nlm.nih.gov/pubmed/35433173
http://dx.doi.org/10.1002/jmd2.12272