Cargando…

Identification of 1, 2, 4-Triazine and Its Derivatives Against Lanosterol 14-Demethylase (CYP51) Property of Candida albicans: Influence on the Development of New Antifungal Therapeutic Strategies

This research aims to find out whether the 1, 2, 4-triazine and its derivatives have antifungal effects and can protect humans from infection with Candida albicans. Molecular docking and molecular dynamic simulation are widely used in modern drug design to target a particular protein with a ligand....

Descripción completa

Detalles Bibliográficos
Autores principales:	Verma, Abhishek Kumar, Majid, Aarfah, Hossain, Md. Shahadat, Ahmed, SK. Faisal, Ashid, Mohammad, Bhojiya, Ali Asger, Upadhyay, Sudhir K., Vishvakarma, Naveen Kumar, Alam, Mudassir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Medical Technology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996309/ https://www.ncbi.nlm.nih.gov/pubmed/35419560 http://dx.doi.org/10.3389/fmedt.2022.845322

Ejemplares similares

Phytochemical profiling of Piper crocatum and its antifungal mechanism action as Lanosterol 14 alpha demethylase CYP51 inhibitor: a review
por: Siswina, Tessa, et al.
Publicado: (2023)

Human Lanosterol 14-Alpha Demethylase (CYP51A1) Is a Putative Target for Natural Flavonoid Luteolin 7,3′-Disulfate
por: Kaluzhskiy, Leonid, et al.
Publicado: (2021)

An Erg11 lanosterol 14-α-demethylase-Arv1 complex is required for Candida albicans virulence
por: Villasmil, Michelle L., et al.
Publicado: (2020)

Computational insights into fluconazole resistance by the suspected mutations in lanosterol 14α-demethylase (Erg11p) of Candida albicans
por: Prakash, Sagunthala Murugesan Udaya, et al.
Publicado: (2020)

Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals
por: Tyndall, Joel D. A., et al.
Publicado: (2016)

Structural Insights into the Azole Resistance of the Candida albicans Darlington Strain Using Saccharomyces cerevisiae Lanosterol 14α-Demethylase as a Surrogate
por: Graham, Danyon O., et al.
Publicado: (2021)

Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa
por: Warrilow, Andrew G. S., et al.
Publicado: (2016)

The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions
por: Warrilow, Andrew G., et al.
Publicado: (2019)

Azole sensitivity in Leptosphaeria pathogens of oilseed rape: the role of lanosterol 14α-demethylase
por: Sewell, Thomas R., et al.
Publicado: (2017)

Small‐Molecule Inhibitors Targeting Sterol 14α‐Demethylase (CYP51): Synthesis, Molecular Modelling and Evaluation Against Candida albicans
por: Binjubair, Faizah A., et al.
Publicado: (2020)

Design, Synthesis and Antifungal Activity Evaluation of New Thiazolin-4-ones as Potential Lanosterol 14α-Demethylase Inhibitors
por: Stana, Anca, et al.
Publicado: (2017)

Point Mutations in the 14-α Sterol Demethylase Cyp51A or Cyp51C Could Contribute to Azole Resistance in Aspergillus flavus
por: Lucio, Jose, et al.
Publicado: (2020)

Interactions of antiparasitic sterols with sterol 14α-demethylase (CYP51) of human pathogens
por: Warfield, Jasmine, et al.
Publicado: (2014)

Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase
por: Sagatova, Alia A., et al.
Publicado: (2016)

Intrinsic short-tailed azole resistance in mucormycetes is due to an evolutionary conserved aminoacid substitution of the lanosterol 14α-demethylase
por: Caramalho, Rita, et al.
Publicado: (2017)

Oxidation of Isodrimeninol with PCC Yields Drimane Derivatives with Activity against Candida Yeast by Inhibition of Lanosterol 14-Alpha Demethylase
por: Marin, Victor, et al.
Publicado: (2020)

Data on molecular docking of tautomers and enantiomers of ATTAF-1 and ATTAF-2 selectivty to the human/fungal lanosterol-14α-demethylase
por: Irannejad, Hamid, et al.
Publicado: (2020)

The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6
por: Scott, Nicola A., et al.
Publicado: (2020)

Functionalized Derivatives of Benzo-Crown Ethers. Part 4. Antifungal Macrocyclic Supramolecular Complexes of Transition Metal Ions Acting as Lanosterol-14-α-Demethylase Ihibitors
por: Barboiu, Mihai, et al.
Publicado: (1999)

Effect of lanosterol on human cataract nucleus
por: Shanmugam, P Mahesh, et al.
Publicado: (2015)

Comment to: Effect of lanosterol on human nuclei
por: Venkatesh, Ramesh, et al.
Publicado: (2016)

Analysis of the ergosterol biosynthesis pathway cloning, molecular characterization and phylogeny of lanosterol 14 α-demethylase (ERG11) gene of Moniliophthora perniciosa
por: de Oliveira Ceita, Geruza, et al.
Publicado: (2014)

Reduced Susceptibility to Azoles in Cryptococcus gattii Correlates with the Substitution R258L in a Substrate Recognition Site of the Lanosterol 14-α-Demethylase
por: Carvajal, Silvia Katherine, et al.
Publicado: (2023)

Processive kinetics in the three-step lanosterol 14α-demethylation reaction catalyzed by human cytochrome P450 51A1
por: McCarty, Kevin D., et al.
Publicado: (2023)

Demethylase Inhibitor Fungicide Resistance in Pyrenophora teres f. sp. teres Associated with Target Site Modification and Inducible Overexpression of Cyp51
por: Mair, Wesley J., et al.
Publicado: (2016)

Failure of Oxysterols Such as Lanosterol to Restore Lens Clarity from Cataracts
por: Daszynski, Damian M., et al.
Publicado: (2019)

Two New Compounds Containing Pyridinone or Triazine Heterocycles Have Antifungal Properties against Candida albicans
por: Mena, Laura, et al.
Publicado: (2022)

Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity
por: Franco, Caio H., et al.
Publicado: (2020)

Analysis of Cyp51 protein sequences shows 4 major Cyp51 gene family groups across fungi
por: Celia-Sanchez, Brandi N, et al.
Publicado: (2022)

Human RAD51 paralogue RAD51C fosters repair of alkylated DNA by interacting with the ALKBH3 demethylase
por: Mohan, Monisha, et al.
Publicado: (2019)

Root Exudates: Mechanistic Insight of Plant Growth Promoting Rhizobacteria for Sustainable Crop Production
por: Upadhyay, Sudhir K., et al.
Publicado: (2022)

Increased lanosterol turnover: a metabolic burden for daunorubicin-resistant leukemia cells
por: Stäubert, Claudia, et al.
Publicado: (2015)

Lanosterol Synthase Pathway Alleviates Lens Opacity in Age-Related Cortical Cataract
por: Shen, Xinyue, et al.
Publicado: (2018)

Construction of antifungal dual-target (SE, CYP51) pharmacophore models and the discovery of novel antifungal inhibitors
por: Dong, Yue, et al.
Publicado: (2019)

Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis
por: Ačimovič, Jure, et al.
Publicado: (2016)

The Oxidosqualene Cyclase from the Oomycete Saprolegnia parasitica Synthesizes Lanosterol as a Single Product
por: Dahlin, Paul, et al.
Publicado: (2016)

Triterpenoid modulates the salt tolerance of lanosterol synthase deficient Saccharomyces cerevisiae, GIL77
por: Inafuku, Masashi, et al.
Publicado: (2018)

Protective Effects of Lanosterol Synthase Up-Regulation in UV-B-Induced Oxidative Stress
por: Hua, Hui, et al.
Publicado: (2019)

Combination of Lanosterol and Nilvadipine Nanosuspensions Rescues Lens Opacification in Selenite-Induced Cataractic Rats
por: Deguchi, Saori, et al.
Publicado: (2022)

Polymorphisms of CYP51A1 from Cholesterol Synthesis: Associations with Birth Weight and Maternal Lipid Levels and Impact on CYP51 Protein Structure
por: Lewińska, Monika, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_fb9d2nbb63s3klh79ah28dacbb