IL-17–induced HIF1α drives resistance to anti–PD-L1 via fibroblast-mediated immune exclusion

Increasing evidence suggests that intratumoral inflammation has an outsized influence on antitumor immunity. Here, we report that IL-17, a proinflammatory cytokine widely associated with poor prognosis in solid tumors, drives the therapeutic failure of anti–PD-L1. By timing the deletion of IL-17 sig...

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Detalles Bibliográficos
Autores principales: Chen, Xing, Zhao, Junjie, Herjan, Tomasz, Hong, Lingzi, Liao, Yun, Liu, Caini, Vasu, Kommireddy, Wang, Han, Thompson, Austin, Fox, Paul L., Gastman, Brian R., Li, Xiao, Li, Xiaoxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996325/
https://www.ncbi.nlm.nih.gov/pubmed/35389431
http://dx.doi.org/10.1084/jem.20210693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996325/
https://www.ncbi.nlm.nih.gov/pubmed/35389431
http://dx.doi.org/10.1084/jem.20210693

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