Proteolysis-targeting chimeras (PROTACs) in cancer therapy

Proteolysis-targeting chimeras (PROTACs) are engineered techniques for targeted protein degradation. A bifunctional PROTAC molecule with two covalently-linked ligands recruits target protein and E3 ubiquitin ligase together to trigger proteasomal degradation of target protein by the ubiquitin-protea...

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Detalles Bibliográficos
Autores principales: Li, Xinyi, Pu, Wenchen, Zheng, Qingquan, Ai, Min, Chen, Song, Peng, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996410/
https://www.ncbi.nlm.nih.gov/pubmed/35410300
http://dx.doi.org/10.1186/s12943-021-01434-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996410/
https://www.ncbi.nlm.nih.gov/pubmed/35410300
http://dx.doi.org/10.1186/s12943-021-01434-3

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