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Regulation of Let-7a-5p and miR-199a-5p Expression by Akt1 Modulates Prostate Cancer Epithelial-to-Mesenchymal Transition via the Transforming Growth Factor-β Pathway

SIMPLE SUMMARY: The molecular mechanisms regulating the switch from the growth of tumor cells to invasive phenotype for metastasis is largely unknown. Molecules such as Akt1 and TGFβ have been demonstrated to play reciprocal roles in the early and advanced stages of cancers, and epithelial-to-mesenc...

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Detalles Bibliográficos
Autores principales: Alwhaibi, Abdulrahman, Parvathagiri, Varun, Verma, Arti, Artham, Sandeep, Adil, Mir S., Somanath, Payaningal R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996869/
https://www.ncbi.nlm.nih.gov/pubmed/35406397
http://dx.doi.org/10.3390/cancers14071625