Cargando…

Tubulin Carboxypeptidase Activity Promotes Focal Gelatin Degradation in Breast Tumor Cells and Induces Apoptosis in Breast Epithelial Cells That Is Overcome by Oncogenic Signaling

SIMPLE SUMMARY: The recent discovery of the genetic identity of the tubulin carboxypeptidase (TCP) provides a unique opportunity to study the role of the detyrosination of α-tubulin (deTyr-Tub), as performed by the TCP, in breast epithelial cells and breast cancer cells. Previous research has shown...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mathias, Trevor J., Ju, Julia A., Lee, Rachel M., Thompson, Keyata N., Mull, Makenzy L., Annis, David A., Chang, Katarina T., Ory, Eleanor C., Stemberger, Megan B., Hotta, Takashi, Ohi, Ryoma, Vitolo, Michele I., Moutin, Marie-Jo, Martin, Stuart S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996877/ https://www.ncbi.nlm.nih.gov/pubmed/35406479 http://dx.doi.org/10.3390/cancers14071707

Ejemplares similares

Hydrogen Peroxide Induces α-Tubulin Detyrosination and Acetylation and Impacts Breast Cancer Metastatic Phenotypes
por: Stemberger, Megan B., et al.
Publicado: (2023)

Elevation of Cytoplasmic Calcium Suppresses Microtentacle Formation and Function in Breast Tumor Cells
por: Chang, Katarina T., et al.
Publicado: (2023)

Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function
por: Pathak, Narendra, et al.
Publicado: (2014)

Stereoselective total synthesis of parthenolides indicates target selectivity for tubulin carboxypeptidase activity
por: Freund, Robert R. A., et al.
Publicado: (2019)

A family of carboxypeptidases catalyzing α- and β-tubulin tail processing and deglutamylation
por: Nicot, Simon, et al.
Publicado: (2023)

CARBOXYPEPTIDASE : III. THE ESTIMATION OF CARBOXYPEPTIDASE AND PRO-CARBOXYPEPTIDASE
por: Anson, M. L.
Publicado: (1937)

Single-Cell Tracking of Breast Cancer Cells Enables Prediction of Sphere Formation from Early Cell Divisions
por: Bailey, Patrick C., et al.
Publicado: (2018)

Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibition
por: Whipple, Rebecca A, et al.
Publicado: (2013)

Knockout of vasohibin‐2 reduces tubulin carboxypeptidase activity and increases paclitaxel sensitivity in ovarian cancer
por: Koyanagi, Takahiro, et al.
Publicado: (2021)

Mechanistic Analysis of CCP1 in Generating ΔC2 α-Tubulin in Mammalian Cells and Photoreceptor Neurons
por: Hotta, Takashi, et al.
Publicado: (2023)

Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters
por: Norris, Stephen R., et al.
Publicado: (2018)

CARBOXYPEPTIDASE : I. THE PREPARATION OF CRYSTALLINE CARBOXYPEPTIDASE
por: Anson, M. L.
Publicado: (1937)

Microtubule minus-end stability is dictated by the tubulin off-rate
por: Strothman, Claire, et al.
Publicado: (2019)

CARBOXYPEPTIDASE : II. THE PARTIAL PURIFICATION OF PRO-CARBOXYPEPTIDASE
por: Anson, M. L.
Publicado: (1937)

Tubulin post‐translational modifications control neuronal development and functions
por: Moutin, Marie‐Jo, et al.
Publicado: (2020)

The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids
por: Tort, Olivia, et al.
Publicado: (2014)

Lipid tethering of breast tumor cells reduces cell aggregation during mammosphere formation
por: Bhandary, Lekhana, et al.
Publicado: (2021)

Diagnostic and Prognostic Significance of Carboxypeptidase A4 (CPA4) in Breast Cancer
por: Bademler, Suleyman, et al.
Publicado: (2019)

Mechanoactivation of NOX2-generated ROS elicits persistent TRPM8 Ca(2+) signals that are inhibited by oncogenic KRas
por: Pratt, Stephen J. P., et al.
Publicado: (2020)

Carboxypeptidase vitellogenic like facilitates resistance to CDK4/6 inhibitors in breast cancer
por: Zhu, Xiang, et al.
Publicado: (2023)

ROCK inhibition promotes microtentacles that enhance reattachment of breast cancer cells
por: Bhandary, Lekhana, et al.
Publicado: (2015)

S-72, a Novel Orally Available Tubulin Inhibitor, Overcomes Paclitaxel Resistance via Inactivation of the STING Pathway in Breast Cancer
por: Hou, Zhenyan, et al.
Publicado: (2023)

Pharmacologic regulation of AMPK in breast cancer affects cytoskeletal properties involved with microtentacle formation and re-attachment
por: Chakrabarti, Kristi R., et al.
Publicado: (2015)

Real-time scratch assay reveals mechanisms of early calcium signaling in breast cancer cells in response to wounding
por: Pratt, Stephen J.P., et al.
Publicado: (2018)

Microtubule-Associated Protein Tau, α-Tubulin and βIII-Tubulin Expression in Breast Cancer
por: Im, Soyoung, et al.
Publicado: (2013)

Carboxypeptidase A4 accumulation is associated with an aggressive phenotype and poor prognosis in triple-negative breast cancer
por: Handa, Tadashi, et al.
Publicado: (2019)

Carboxypeptidase A4 negatively correlates with p53 expression and regulates the stemness of breast cancer cells
por: Wang, Yipeng, et al.
Publicado: (2021)

Measurement of carboxypeptidase R by colorimetric assay
por: Komura, H, et al.
Publicado: (2002)

Regulation of Chemerin Bioactivity by Plasma Carboxypeptidase N, Carboxypeptidase B (Activated Thrombin-activable Fibrinolysis Inhibitor), and Platelets
por: Du, Xiao-Yan, et al.
Publicado: (2009)

Carboxypeptidase N1 is anticipated to be a synergy metrics for chemotherapy effectiveness and prognostic significance in invasive breast cancer
por: Cui, Ranliang, et al.
Publicado: (2021)

Prolyl Carboxypeptidase Maintains Receptor Tyrosine Kinase Signaling and Is a Potential Therapeutic Target in Triple Negative Breast Cancer
por: Duan, Lei, et al.
Publicado: (2022)

Arsenic Trioxide Overcomes Rapamycin-Induced Feedback Activation of AKT and ERK Signaling to Enhance the Anti-Tumor Effects in Breast Cancer
por: Guilbert, Cynthia, et al.
Publicado: (2013)

Regulation of dopamine transporter activity by carboxypeptidase E
por: Zhang, Heping, et al.
Publicado: (2009)

Characterization of glutamate carboxypeptidase 2 orthologs in trematodes
por: Jedlickova, Lucie, et al.
Publicado: (2022)

HIF-1α-Dependent Induction of Carboxypeptidase A4 and Carboxypeptidase E in Hypoxic Human Adipose-Derived Stem Cells
por: Moon, Yunwon, et al.
Publicado: (2020)

Evidence for new C-terminally truncated variants of α- and β-tubulins
por: Aillaud, Chrystelle, et al.
Publicado: (2016)

Crosstalk between acetylation and the tyrosination/detyrosination cycle of α-tubulin in Alzheimer’s disease
por: Martínez-Hernández, José, et al.
Publicado: (2022)

β class II tubulin predominates in normal and tumor breast tissues
por: Dozier, James H, et al.
Publicado: (2003)

Resistance and Overcoming Resistance in Breast Cancer
por: Luque-Bolivar, Andrea, et al.
Publicado: (2020)

Ambivalent roles of carboxypeptidase B in the lytic susceptibility of fibrin()
por: Kovács, András, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_n63e7k5kpdik8h0gsl779a7cnd