Cargando…

Krüppel-like Factor 9 (KLF9) Suppresses Hepatocellular Carcinoma (HCC)-Promoting Oxidative Stress and Inflammation in Mice Fed High-Fat Diet

SIMPLE SUMMARY: The nuclear protein Krüppel-like factor 9 (KLF9) suppresses development of cancers in multiple tissues including the liver. However, a mechanistic basis for how KLF9 decreases cancer initiation/development has not been elucidated. Here, we used a mouse model in which the Klf9 gene wa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brown, Adam R., Alhallak, Iad, Simmen, Rosalia C. M., Melnyk, Stepan B., Heard-Lipsmeyer, Melissa E., Montales, Maria Theresa E., Habenicht, Daniel, Van, Trang T., Simmen, Frank A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996893/ https://www.ncbi.nlm.nih.gov/pubmed/35406507 http://dx.doi.org/10.3390/cancers14071737

Ejemplares similares

Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice
por: Heard-Lipsmeyer, Melissa E., et al.
Publicado: (2021)

The Krüppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression
por: Simmen, Frank A, et al.
Publicado: (2008)

Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice
por: Simmen, Frank A., et al.
Publicado: (2023)

Co-Morbidity of Type 1 Diabetes Promotes Endometriosis Status-A Pilot Study
por: Alhallak, Iad, et al.
Publicado: (2021)

A Pilot Study on the Co-existence of Diabetes and Endometriosis in Reproductive-Age Women: Potential for Endometriosis Progression
por: Alhallak, Iad, et al.
Publicado: (2023)

Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells
por: Pabona, John Mark P, et al.
Publicado: (2020)

SUN-126 Distinct Molecular Phenotypes of Non-Diseased Breast Adipose Tissue of Pre-Menopausal Obese and Non-Obese Women May Underlie Differing Breast Cancer Risks
por: Alhallak, Iad, et al.
Publicado: (2020)

Metformin regulation of progesterone receptor isoform-B expression in human endometrial cancer cells is glucose-dependent
por: Saguyod, Sofia Jade U., et al.
Publicado: (2020)

Krüppel-like factor 9 (KLF9) links hormone dysregulation and circadian disruption to breast cancer pathogenesis
por: Ybañez, Weand S., et al.
Publicado: (2023)

Cytosolic Malic Enzyme 1 (ME1) Mediates High Fat Diet-Induced Adiposity, Endocrine Profile, and Gastrointestinal Tract Proliferation-Associated Biomarkers in Male Mice
por: Al-Dwairi, Ahmed, et al.
Publicado: (2012)

Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis
por: Bureau, Christophe, et al.
Publicado: (2009)

The Role of Thyroid Hormone Signaling in the Prevention of Digestive System Cancers
por: Brown, Adam R., et al.
Publicado: (2013)

Krüppel-like Factor 2 (KLF2) in Immune Cell Migration
por: Wittner, Jens, et al.
Publicado: (2021)

Kruppel-Like Factor 4 (KLF4) and its Regulation on Mitochondrial Homeostasis
por: Tung, Brian, et al.
Publicado: (2018)

Specificity Proteins (SP) and Krüppel-like Factors (KLF) in Liver Physiology and Pathology
por: Yerra, Veera Ganesh, et al.
Publicado: (2023)

Prior Statin vs In-Hospital Statin Usage in Severe COVID-19: Review and Meta-Analysis
por: Alhallak, Iad, et al.
Publicado: (2023)

Krüppel-Like Factor KLF8 Plays a Critical Role in Adipocyte Differentiation
por: Lee, Haemi, et al.
Publicado: (2012)

Krüppel-Like Factor 4 (KLF4) Is Not Required for Retinal Cell Differentiation123
por: Fang, Jiahua, et al.
Publicado: (2016)

Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)
por: Knights, Alexander J., et al.
Publicado: (2020)

A Novel Role for Kruppel-like Factor 14 (KLF14) in T-Regulatory Cell Differentiation
por: Sarmento, Olga F., et al.
Publicado: (2014)

Expression and Clinical Significance of Serum Krüppel-Like Factor 7 (KLF7) in NSCLC Patients
por: Song, Huigai, et al.
Publicado: (2022)

Molecular function of Krüppel-like factor 7 in biology: Molecular function of KLF7 in biology
por: Mao, Yi, et al.
Publicado: (2023)

The transcription factor ELF4 controls proliferation and homing of CD8(+) T cells via the Krüppel-like factors KLF4 and KLF2
por: Yamada, Takeshi, et al.
Publicado: (2009)

Lovastatin induced Kruppel like factor 2 (KLF2), Kruppel like factor 6 (KLF6) and Ras homolog family member B (RHOB) genes and preferentially led to viability reduction of Cisplatin-resistant cells
por: Koi, Chiho, et al.
Publicado: (2017)

Fat mass and obesity associated (FTO)-mediated N6-methyladenosine modification of Krüppel-like factor 3 (KLF3) promotes osteosarcoma progression
por: Shan, Hong-Jian, et al.
Publicado: (2022)

KLF9 (Kruppel Like Factor 9) induced PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2, 6-Biphosphatase 3) downregulation inhibits the proliferation, metastasis and aerobic glycolysis of cutaneous squamous cell carcinoma cells
por: Xing, Jiahua, et al.
Publicado: (2021)

The Krüppel-like factor (KLF5) as a predictive biomarker in preoperative chemoradiation therapy for rectal cancer
por: Kim, Jeong Yeon, et al.
Publicado: (2019)

Six Shades of Vascular Smooth Muscle Cells Illuminated by KLF4 (Krüppel-Like Factor 4)
por: Yap, Carmen, et al.
Publicado: (2021)

Mechanism of KLF9 in airway inflammation in chronic obstructive pulmonary
por: Gu, Peijie, et al.
Publicado: (2023)

Enhanced Gastrointestinal Expression of Cytosolic Malic Enzyme (ME1) Induces Intestinal and Liver Lipogenic Gene Expression and Intestinal Cell Proliferation in Mice
por: Al-Dwairi, Ahmed, et al.
Publicado: (2014)

Malic Enzyme 1 (ME1) is pro-oncogenic in Apc(Min/+) mice
por: Fernandes, Lorenzo M., et al.
Publicado: (2018)

Expression of Krüppel-like factor 9 in breast cancer patients and its effect on prognosis
por: Jiang, Zirong, et al.
Publicado: (2020)

Loss of Krüppel-like factor 9 deregulates both physiological gene expression and development
por: Drepanos, Laura, et al.
Publicado: (2023)

Hepatic Krüppel-like factor 16 (KLF16) targets PPARα to improve steatohepatitis and insulin resistance
por: Sun, Nannan, et al.
Publicado: (2021)

Mesenchymal Mycn participates in odontoblastic lineage commitment by regulating Krüppel-like Factor 4 (Klf4) in mice
por: Huang, Zhuo, et al.
Publicado: (2022)

Detailed Structural-Functional Analysis of the Krüppel-like Factor 16 (KLF16) Transcription Factor Reveals Novel Mechanisms for Silencing Sp/KLF Sites Involved in Metabolism and Endocrinology
por: Daftary, Gaurang S., et al.
Publicado: (2012)

KLF9 and KLF13 transcription factors boost myelin gene expression in oligodendrocytes as partners of SOX10 and MYRF
por: Bernhardt, Celine, et al.
Publicado: (2022)

OR01-04 Kruppel-Like Factors 9 and 13 Cooperate to Maintain Mammalian Neuronal Differentiation
por: Avila-Mendoza, Jose, et al.
Publicado: (2020)

Glucocorticoid-Responsive Transcription Factor Krüppel-Like Factor 9 Regulates fkbp5 and Metabolism
por: Gans, Ian M., et al.
Publicado: (2021)

Prognostic value and immunological role of Kruppel-like transcription factor 9 gene in pan-carcinoma
por: Cai, Weichao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_j8eivksjlr7ut666gt0qpac6mm