YY1 Oligomerization Is Regulated by Its OPB Domain and Competes with Its Regulation of Oncoproteins

SIMPLE SUMMARY: YY1 regulates various cancer-related genes and activates key oncoproteins. In this study, we discovered that the oncoprotein binding (OPB) domain of YY1 is both necessary and stimulatory to its oligomerization. The hydrophobic residues, especially F219, in the OPB are essential to YY...

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Detalles Bibliográficos
Autores principales: Qiao, Shiyao, Wang, Wenmeng, Yi, Cheng, Xu, Qingqing, Wang, Wenfei, Shi, Jinming, Stovall, Daniel B., Li, Dangdang, Sui, Guangchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996997/
https://www.ncbi.nlm.nih.gov/pubmed/35406384
http://dx.doi.org/10.3390/cancers14071611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996997/
https://www.ncbi.nlm.nih.gov/pubmed/35406384
http://dx.doi.org/10.3390/cancers14071611

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