ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors

SIMPLE SUMMARY: High-grade glioma has a poor prognosis and new effective strategies to treat this aggressive form of cancer are highly needed. We have conducted a drug screen searching for compounds toxic to ATRX-deficient cells, a frequent scenario in cancer, and particularly in high-grade gliomas....

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Detalles Bibliográficos
Autores principales: Pladevall-Morera, David, Castejón-Griñán, María, Aguilera, Paula, Gaardahl, Karina, Ingham, Andreas, Brosnan-Cashman, Jacqueline A., Meeker, Alan K., Lopez-Contreras, Andres J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997088/
https://www.ncbi.nlm.nih.gov/pubmed/35406561
http://dx.doi.org/10.3390/cancers14071790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997088/
https://www.ncbi.nlm.nih.gov/pubmed/35406561
http://dx.doi.org/10.3390/cancers14071790

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