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Hepatic PPARα Is Destabilized by SIRT1 Deacetylase in Undernourished Male Mice
The nutrient sensing nuclear receptor peroxisome proliferator-activated receptor-α (PPARα) regulates the host response to short-term fasting by inducing hepatic transcriptional programming of ketogenesis, fatty acid oxidation and transport, and autophagy. This adaptation is ineffective in chronicall...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997242/ https://www.ncbi.nlm.nih.gov/pubmed/35419389 http://dx.doi.org/10.3389/fnut.2022.831879 |