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The perfect PTEN – transcriptional regulation by PTEN dictates sarcoma identity
Fusion-negative rhabdomyosarcoma (FN-RMS) is molecularly heterogeneous with few universal alterations except for Phosphatase and tensin homolog (PTEN) promoter hypermethylation. We demonstrate that losing Pten in FN-RMS engages an aberrant transcriptional program key in tumor maintenance and cell id...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997253/ https://www.ncbi.nlm.nih.gov/pubmed/35419479 http://dx.doi.org/10.1080/23723556.2021.2002120 |