The perfect PTEN – transcriptional regulation by PTEN dictates sarcoma identity

Fusion-negative rhabdomyosarcoma (FN-RMS) is molecularly heterogeneous with few universal alterations except for Phosphatase and tensin homolog (PTEN) promoter hypermethylation. We demonstrate that losing Pten in FN-RMS engages an aberrant transcriptional program key in tumor maintenance and cell id...

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Detalles Bibliográficos
Autores principales: Langdon, Casey G., Hatley, Mark E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997253/
https://www.ncbi.nlm.nih.gov/pubmed/35419479
http://dx.doi.org/10.1080/23723556.2021.2002120
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author Langdon, Casey G.
Hatley, Mark E.
author_facet Langdon, Casey G.
Hatley, Mark E.
author_sort Langdon, Casey G.
collection PubMed
description Fusion-negative rhabdomyosarcoma (FN-RMS) is molecularly heterogeneous with few universal alterations except for Phosphatase and tensin homolog (PTEN) promoter hypermethylation. We demonstrate that losing Pten in FN-RMS engages an aberrant transcriptional program key in tumor maintenance and cell identity. These results highlight the importance between transcriptional state, cell of origin, and genetic perturbation in tumorigenesis.
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spelling pubmed-89972532022-04-12 The perfect PTEN – transcriptional regulation by PTEN dictates sarcoma identity Langdon, Casey G. Hatley, Mark E. Mol Cell Oncol Author’s Views Fusion-negative rhabdomyosarcoma (FN-RMS) is molecularly heterogeneous with few universal alterations except for Phosphatase and tensin homolog (PTEN) promoter hypermethylation. We demonstrate that losing Pten in FN-RMS engages an aberrant transcriptional program key in tumor maintenance and cell identity. These results highlight the importance between transcriptional state, cell of origin, and genetic perturbation in tumorigenesis. Taylor & Francis 2021-11-22 /pmc/articles/PMC8997253/ /pubmed/35419479 http://dx.doi.org/10.1080/23723556.2021.2002120 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Langdon, Casey G.
Hatley, Mark E.
The perfect PTEN – transcriptional regulation by PTEN dictates sarcoma identity
title The perfect PTEN – transcriptional regulation by PTEN dictates sarcoma identity
title_full The perfect PTEN – transcriptional regulation by PTEN dictates sarcoma identity
title_fullStr The perfect PTEN – transcriptional regulation by PTEN dictates sarcoma identity
title_full_unstemmed The perfect PTEN – transcriptional regulation by PTEN dictates sarcoma identity
title_short The perfect PTEN – transcriptional regulation by PTEN dictates sarcoma identity
title_sort perfect pten – transcriptional regulation by pten dictates sarcoma identity
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997253/
https://www.ncbi.nlm.nih.gov/pubmed/35419479
http://dx.doi.org/10.1080/23723556.2021.2002120
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