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The perfect PTEN – transcriptional regulation by PTEN dictates sarcoma identity

Fusion-negative rhabdomyosarcoma (FN-RMS) is molecularly heterogeneous with few universal alterations except for Phosphatase and tensin homolog (PTEN) promoter hypermethylation. We demonstrate that losing Pten in FN-RMS engages an aberrant transcriptional program key in tumor maintenance and cell id...

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Detalles Bibliográficos
Autores principales:	Langdon, Casey G., Hatley, Mark E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Author’s Views
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997253/ https://www.ncbi.nlm.nih.gov/pubmed/35419479 http://dx.doi.org/10.1080/23723556.2021.2002120

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