MYC overexpression leads to increased chromatin interactions at super-enhancers and MYC binding sites

The MYC oncogene encodes for the MYC protein and is frequently dysregulated across multiple cancer cell types, making it an attractive target for cancer therapy. MYC overexpression leads to MYC binding at active enhancers, resulting in a global transcriptional amplification of active genes. Because...

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Detalles Bibliográficos
Autores principales: See, Yi Xiang, Chen, Kaijing, Fullwood, Melissa J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997345/
https://www.ncbi.nlm.nih.gov/pubmed/35115371
http://dx.doi.org/10.1101/gr.276313.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997345/
https://www.ncbi.nlm.nih.gov/pubmed/35115371
http://dx.doi.org/10.1101/gr.276313.121

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