Somatic structural variant formation is guided by and influences genome architecture

The occurrence and formation of genomic structural variants (SVs) is known to be influenced by the 3D chromatin architecture, but the extent and magnitude have been challenging to study. Here, we apply Hi-C to study chromatin organization before and after induction of chromothripsis in human cells....

Descripción completa

Detalles Bibliográficos
Autores principales: Sidiropoulos, Nikos, Mardin, Balca R., Rodríguez-González, F. Germán, Bochkov, Ivan D., Garg, Shilpa, Stütz, Adrian M., Korbel, Jan O., Aiden, Erez Lieberman, Weischenfeldt, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997353/
https://www.ncbi.nlm.nih.gov/pubmed/35177558
http://dx.doi.org/10.1101/gr.275790.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997353/
https://www.ncbi.nlm.nih.gov/pubmed/35177558
http://dx.doi.org/10.1101/gr.275790.121

Ejemplares similares