Expression of CD47 and SIRPα Macrophage Immune-Checkpoint Pathway in Non-Small-Cell Lung Cancer

SIMPLE SUMMARY: Cancer cells escape macrophage phagocytosis by exploiting the CD47/SIRPα axis. We found that extensive membranous CD47 expression by cancer cells characterized 29/98 cases. SIRPα and CD68 were expressed by tumor-associated macrophages (Μφ, TAMs). A high CD68Mφ-score was linked with i...

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Detalles Bibliográficos
Autores principales: Giatromanolaki, Alexandra, Mitrakas, Achilleas, Anestopoulos, Ioannis, Kontosis, Andreas, Koukourakis, Ioannis M., Pappa, Aglaia, Panayiotidis, Mihalis I., Koukourakis, Michael I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997641/
https://www.ncbi.nlm.nih.gov/pubmed/35406573
http://dx.doi.org/10.3390/cancers14071801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997641/
https://www.ncbi.nlm.nih.gov/pubmed/35406573
http://dx.doi.org/10.3390/cancers14071801

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