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Expression of CD47 and SIRPα Macrophage Immune-Checkpoint Pathway in Non-Small-Cell Lung Cancer
SIMPLE SUMMARY: Cancer cells escape macrophage phagocytosis by exploiting the CD47/SIRPα axis. We found that extensive membranous CD47 expression by cancer cells characterized 29/98 cases. SIRPα and CD68 were expressed by tumor-associated macrophages (Μφ, TAMs). A high CD68Mφ-score was linked with i...
Autores principales: | Giatromanolaki, Alexandra, Mitrakas, Achilleas, Anestopoulos, Ioannis, Kontosis, Andreas, Koukourakis, Ioannis M., Pappa, Aglaia, Panayiotidis, Mihalis I., Koukourakis, Michael I. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997641/ https://www.ncbi.nlm.nih.gov/pubmed/35406573 http://dx.doi.org/10.3390/cancers14071801 |
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