D-Cysteine Activates Chaperone-Mediated Autophagy in Cerebellar Purkinje Cells via the Generation of Hydrogen Sulfide and Nrf2 Activation

Chaperone-mediated autophagy (CMA) is a pathway in the autophagy-lysosome protein degradation system. CMA impairment has been implicated to play a role in spinocerebellar ataxia (SCA) pathogenesis. D-cysteine is metabolized by D-amino acid oxidase (DAO), leading to hydrogen sulfide generation in the...

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Detalles Bibliográficos
Autores principales: Ueda, Erika, Ohta, Tomoko, Konno, Ayumu, Hirai, Hirokazu, Kurauchi, Yuki, Katsuki, Hiroshi, Seki, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997644/
https://www.ncbi.nlm.nih.gov/pubmed/35406792
http://dx.doi.org/10.3390/cells11071230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997644/
https://www.ncbi.nlm.nih.gov/pubmed/35406792
http://dx.doi.org/10.3390/cells11071230

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