Molecular and Functional Signatures Associated with CAR T Cell Exhaustion and Impaired Clinical Response in Patients with B Cell Malignancies

Despite the high rates of complete remission following chimeric antigen receptor (CAR) T cell therapy, its full capacity is currently limited by the generation of dysfunctional CAR T cells. Senescent or exhausted CAR T cells possess poor targeting and effector functions, as well as impaired cell pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Beider, Katia, Itzhaki, Orit, Schachter, Jacob, Grushchenko-Polaq, Ania Hava, Voevoda-Dimenshtein, Valeria, Rosenberg, Evgenia, Ostrovsky, Olga, Devillers, Olivia, Shapira Frommer, Ronnie, Zeltzer, Li-at, Toren, Amos, Jacoby, Elad, Shimoni, Avichai, Avigdor, Abraham, Nagler, Arnon, Besser, Michal J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997745/
https://www.ncbi.nlm.nih.gov/pubmed/35406703
http://dx.doi.org/10.3390/cells11071140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997745/
https://www.ncbi.nlm.nih.gov/pubmed/35406703
http://dx.doi.org/10.3390/cells11071140

Ejemplares similares