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Molecular and Functional Signatures Associated with CAR T Cell Exhaustion and Impaired Clinical Response in Patients with B Cell Malignancies

Despite the high rates of complete remission following chimeric antigen receptor (CAR) T cell therapy, its full capacity is currently limited by the generation of dysfunctional CAR T cells. Senescent or exhausted CAR T cells possess poor targeting and effector functions, as well as impaired cell pro...

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Detalles Bibliográficos
Autores principales:	Beider, Katia, Itzhaki, Orit, Schachter, Jacob, Grushchenko-Polaq, Ania Hava, Voevoda-Dimenshtein, Valeria, Rosenberg, Evgenia, Ostrovsky, Olga, Devillers, Olivia, Shapira Frommer, Ronnie, Zeltzer, Li-at, Toren, Amos, Jacoby, Elad, Shimoni, Avichai, Avigdor, Abraham, Nagler, Arnon, Besser, Michal J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997745/ https://www.ncbi.nlm.nih.gov/pubmed/35406703 http://dx.doi.org/10.3390/cells11071140

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