Functional Characterization of Rare Variants in OAT1/SLC22A6 and OAT3/SLC22A8 Urate Transporters Identified in a Gout and Hyperuricemia Cohort

The OAT1 (SLC22A6) and OAT3 (SLC22A8) urate transporters are located on the basolateral membrane of the proximal renal tubules, where they ensure the uptake of uric acid from the urine back into the body. In a cohort of 150 Czech patients with primary hyperuricemia and gout, we examined the coding r...

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Detalles Bibliográficos
Autores principales: Vávra, Jiří, Mančíková, Andrea, Pavelcová, Kateřina, Hasíková, Lenka, Bohatá, Jana, Stibůrková, Blanka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997829/
https://www.ncbi.nlm.nih.gov/pubmed/35406626
http://dx.doi.org/10.3390/cells11071063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997829/
https://www.ncbi.nlm.nih.gov/pubmed/35406626
http://dx.doi.org/10.3390/cells11071063

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