Simvastatin Prevents Liver Microthrombosis and Sepsis Induced Coagulopathy in a Rat Model of Endotoxemia

Background: Endotoxemia causes endothelial dysfunction and microthrombosis, which are pathogenic mechanisms of coagulopathy and organ failure during sepsis. Simvastatin has potential anti-thrombotic effects on liver endothelial cells. We investigated the hemostatic changes induced by lipopolysacchar...

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Detalles Bibliográficos
Autores principales: La Mura, Vincenzo, Gagliano, Nicoletta, Arnaboldi, Francesca, Sartori, Patrizia, Procacci, Patrizia, Denti, Luca, Liguori, Eleonora, Bitto, Niccolò, Ristagno, Giuseppe, Latini, Roberto, Dondossola, Daniele, Salerno, Francesco, Tripodi, Armando, Colombo, Massimo, Peyvandi, Flora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997834/
https://www.ncbi.nlm.nih.gov/pubmed/35406712
http://dx.doi.org/10.3390/cells11071148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997834/
https://www.ncbi.nlm.nih.gov/pubmed/35406712
http://dx.doi.org/10.3390/cells11071148

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