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Simvastatin Prevents Liver Microthrombosis and Sepsis Induced Coagulopathy in a Rat Model of Endotoxemia
Background: Endotoxemia causes endothelial dysfunction and microthrombosis, which are pathogenic mechanisms of coagulopathy and organ failure during sepsis. Simvastatin has potential anti-thrombotic effects on liver endothelial cells. We investigated the hemostatic changes induced by lipopolysacchar...
Autores principales: | La Mura, Vincenzo, Gagliano, Nicoletta, Arnaboldi, Francesca, Sartori, Patrizia, Procacci, Patrizia, Denti, Luca, Liguori, Eleonora, Bitto, Niccolò, Ristagno, Giuseppe, Latini, Roberto, Dondossola, Daniele, Salerno, Francesco, Tripodi, Armando, Colombo, Massimo, Peyvandi, Flora |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997834/ https://www.ncbi.nlm.nih.gov/pubmed/35406712 http://dx.doi.org/10.3390/cells11071148 |
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