Therapeutic Efficacy of Pharmacological Ascorbate on Braf Inhibitor Resistant Melanoma Cells In Vitro and In Vivo

High-dose ascorbate paradoxically acts as a pro-oxidant causing the formation of hydrogen peroxide in an oxygen dependent manner. Tumor cells (in particular melanoma cells) show an increased vulnerability to ascorbate induced reactive oxygen species (ROS). Therefore, high-dose ascorbate is a promisi...

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Detalles Bibliográficos
Autores principales: Niessner, Heike, Burkard, Markus, Leischner, Christian, Renner, Olga, Plöger, Sarah, Meraz-Torres, Francisco, Böcker, Matti, Hirn, Constanze, Lauer, Ulrich M., Venturelli, Sascha, Busch, Christian, Sinnberg, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997901/
https://www.ncbi.nlm.nih.gov/pubmed/35406796
http://dx.doi.org/10.3390/cells11071229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8997901/
https://www.ncbi.nlm.nih.gov/pubmed/35406796
http://dx.doi.org/10.3390/cells11071229

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