Role of Glucocorticoid Signaling and HDAC4 Activation in Diaphragm and Gastrocnemius Proteolytic Activity in Septic Rats

Sepsis increases glucocorticoid and decreases IGF-1, leading to skeletal muscle wasting and cachexia. Muscle atrophy mainly takes place in locomotor muscles rather than in respiratory ones. Our study aimed to elucidate the mechanism responsible for this difference in muscle proteolysis, focusing on...

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Detalles Bibliográficos
Autores principales: Moreno-Rupérez, Álvaro, Priego, Teresa, González-Nicolás, María Ángeles, López-Calderón, Asunción, Lázaro, Alberto, Martín, Ana Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998191/
https://www.ncbi.nlm.nih.gov/pubmed/35408999
http://dx.doi.org/10.3390/ijms23073641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998191/
https://www.ncbi.nlm.nih.gov/pubmed/35408999
http://dx.doi.org/10.3390/ijms23073641

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