Cargando…

Mechanistic Insight into the Mode of Action of Acid β-Glucosidase Enhancer Ambroxol

Ambroxol (ABX) is a mucolytic agent used for the treatment of respiratory diseases. Bioactivity has been demonstrated as an enhancement effect on lysosomal acid β-glucosidase (β-Glu) activity in Gaucher disease (GD). The positive effects observed have been attributed to a mechanism of action similar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pantoom, Supansa, Hules, Larissa, Schöll, Christopher, Petrosyan, Andranik, Monticelli, Maria, Pospech, Jola, Cubellis, Maria Vittoria, Hermann, Andreas, Lukas, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998264/ https://www.ncbi.nlm.nih.gov/pubmed/35408914 http://dx.doi.org/10.3390/ijms23073536

Ejemplares similares

Pyrimidopteridine‐catalyzed Photo‐mediated Hydroacetoxylation
por: Petrosyan, Andranik, et al.
Publicado: (2022)

Assessment of Gene Variant Amenability for Pharmacological Chaperone Therapy with 1-Deoxygalactonojirimycin in Fabry Disease
por: Lukas, Jan, et al.
Publicado: (2020)

Substrate binding modes and anomer selectivity of chitinase A from Vibrio harveyi
por: Suginta, Wipa, et al.
Publicado: (2009)

1-[(Methylsulfonyl)oxy]pyridin-1-ium methanesulfonate
por: Taeufer, Tobias, et al.
Publicado: (2021)

Assessment of FDA-Approved Drugs as a Therapeutic Approach for Niemann-Pick Disease Type C1 Using Patient-Specific iPSC-Based Model Systems
por: Völkner, Christin, et al.
Publicado: (2022)

The effects of the surface-exposed residues on the binding and hydrolytic activities of Vibrio carchariae chitinase A
por: Pantoom, Supansa, et al.
Publicado: (2008)

Direct Interaction of ATP7B and LC3B Proteins Suggests a Cooperative Role of Copper Transportation and Autophagy
por: Pantoom, Supansa, et al.
Publicado: (2021)

Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins
por: Yang, Aimin, et al.
Publicado: (2017)

Distinct Mechanisms for Processing Autophagy Protein LC3‐PE by RavZ and ATG4B
por: Yang, Aimin, et al.
Publicado: (2020)

Looking for protein stabilizing drugs with thermal shift assay
por: Andreotti, Giuseppina, et al.
Publicado: (2015)

Different ventilation modes combined with ambroxol in the treatment of respiratory distress syndrome in premature infants
por: Zhou, Bin, et al.
Publicado: (2017)

Ambroxol for the treatment of fibromyalgia: science or fiction?
por: Kern, Kai-Uwe, et al.
Publicado: (2017)

Value of ambroxol in the treatment of asthmatic bronchitis
por: Du, Xiaoxia, et al.
Publicado: (2020)

Polypharmacology of ambroxol in the treatment of COVID-19
por: Wang, Ziyuan, et al.
Publicado: (2023)

Use of Ambroxol as Therapy for Gaucher Disease
por: Zhan, Xia, et al.
Publicado: (2023)

Thermo-Analytical and Compatibility Study with Mechanistic Explanation of Degradation Kinetics of Ambroxol Hydrochloride Tablets under Non-Isothermal Conditions
por: Jelić, Dijana, et al.
Publicado: (2021)

Mechanistic Insights into the Antibiofilm Mode of Action of Ellagic Acid
por: Ratti, Alessandro, et al.
Publicado: (2023)

Ambroxol as a pharmacological chaperone for mutant glucocerebrosidase
por: Bendikov-Bar, Inna, et al.
Publicado: (2013)

Immunomodulatory Effects of Ambroxol on Airway Hyperresponsiveness and Inflammation
por: Takeda, Katsuyuki, et al.
Publicado: (2016)

β-Glucose-1,6-Bisphosphate Stabilizes Pathological Phophomannomutase2 Mutants In Vitro and Represents a Lead Compound to Develop Pharmacological Chaperones for the Most Common Disorder of Glycosylation, PMM2-CDG
por: Monticelli, Maria, et al.
Publicado: (2019)

Pharmacological Chaperones: A Therapeutic Approach for Diseases Caused by Destabilizing Missense Mutations
por: Liguori, Ludovica, et al.
Publicado: (2020)

Comparison of the Physicochemical Properties, Antimicrobial Action, and Cytotoxicity of Ambroxol Hydrochloride, N-acetylcysteine, and Calcium Hydroxide Pastes
por: Calefi, Pedro Henrique Souza, et al.
Publicado: (2022)

Bioinformatics tools for marine biotechnology: a practical tutorial with a metagenomic approach
por: Liguori, Ludovica, et al.
Publicado: (2020)

Why does SARS-CoV-2 hit in different ways? Host genetic factors can influence the acquisition or the course of COVID-19
por: Monticelli, Maria, et al.
Publicado: (2021)

Efficacy of Ambroxol lozenges for pharyngitis: a meta-analysis
por: Chenot, Jean-François, et al.
Publicado: (2014)

Ambroxol effects in glucocerebrosidase and α‐synuclein transgenic mice
por: Migdalska‐Richards, Anna, et al.
Publicado: (2016)

Mechanistic insights into mode of action of novel natural cathepsin L inhibitors
por: Tyagi, Chetna, et al.
Publicado: (2013)

Lead Toxicity in Cereals: Mechanistic Insight Into Toxicity, Mode of Action, and Management
por: Aslam, Muhammad, et al.
Publicado: (2021)

Congenital disorders of glycosylation: narration of a story through its patents
por: Monticelli, Maria, et al.
Publicado: (2023)

Ambroxol: utilidad en la enfermedad de menbrana hiliana
por: Reyes Salazar, Gonzálo
Publicado: (1995)

Preparation and Evaluation of Microencapsulated Fast Melt Tablets of Ambroxol Hydrochloride
por: Jacob, S., et al.
Publicado: (2009)

The protective effects of Ambroxol in Pseudomonas aeruginosa-induced pneumonia in rats
por: Gao, Xiwen, et al.
Publicado: (2011)

Simultaneous UV Spectrophotometric Estimation of Ambroxol Hydrochloride and Levocetirizine Dihydrochloride
por: Prabhu, S. Lakshmana, et al.
Publicado: (2008)

Enhanced Controlled Transdermal Delivery of Ambroxol from the EVA Matrix
por: Cho, C. W., et al.
Publicado: (2012)

Azithromycin and ambroxol as potential pharmacotherapy for SARS-CoV-2
por: Alkotaji, Myasar
Publicado: (2020)

Ambroxol Treatment Suppresses the Proliferation of Chlamydia pneumoniae in Murine Lungs
por: Kókai, Dávid, et al.
Publicado: (2021)

Does Ambroxol alleviate kidney ischemia-reperfusion injury in rats?
por: Gültekin, Çağrı, et al.
Publicado: (2022)

RAB33B recruits the ATG16L1 complex to the phagophore via a noncanonical RAB binding protein
por: Pantoom, Supansa, et al.
Publicado: (2020)

Curcumin Has Beneficial Effects on Lysosomal Alpha-Galactosidase: Potential Implications for the Cure of Fabry Disease
por: Monticelli, Maria, et al.
Publicado: (2023)

Oxidative Stress in Dairy Cows: Insights into the Mechanistic Mode of Actions and Mitigating Strategies
por: Ayemele, Aurele Gnetegha, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_2d15fjduetma0f1ar8k6ph8205