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A Pharmacokinetic and Metabolism Study of the TRPC6 Inhibitor SH045 in Mice by LC-MS/MS

TRPC6, the sixth member of the family of canonical transient receptor potential (TRP) channels, contributes to a variety of physiological processes and human pathologies. This study extends the knowledge on the newly developed TRPC6 blocker SH045 with respect to its main target organs beyond the des...

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Detalles Bibliográficos
Autores principales: Chai, Xiao-Ning, Ludwig, Friedrich-Alexander, Müglitz, Anne, Gong, Yuanyuan, Schaefer, Michael, Regenthal, Ralf, Krügel, Ute
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998618/
https://www.ncbi.nlm.nih.gov/pubmed/35408998
http://dx.doi.org/10.3390/ijms23073635