Effect of Metformin on T2D-Induced MAM Ca(2+) Uncoupling and Contractile Dysfunction in an Early Mouse Model of Diabetic HFpEF

Diabetic cardiomyopathy (DCM) is a leading complication in type 2 diabetes patients. Recently, we have shown that the reticulum-mitochondria Ca(2+) uncoupling is an early and reversible trigger of the cardiac dysfunction in a diet-induced mouse model of DCM. Metformin is a first-line antidiabetic dr...

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Detalles Bibliográficos
Autores principales: Dia, Maya, Leon, Christelle, Chanon, Stephanie, Bendridi, Nadia, Gomez, Ludovic, Rieusset, Jennifer, Thibault, Helene, Paillard, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998623/
https://www.ncbi.nlm.nih.gov/pubmed/35408928
http://dx.doi.org/10.3390/ijms23073569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998623/
https://www.ncbi.nlm.nih.gov/pubmed/35408928
http://dx.doi.org/10.3390/ijms23073569

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