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Effect of Metformin on T2D-Induced MAM Ca(2+) Uncoupling and Contractile Dysfunction in an Early Mouse Model of Diabetic HFpEF
Diabetic cardiomyopathy (DCM) is a leading complication in type 2 diabetes patients. Recently, we have shown that the reticulum-mitochondria Ca(2+) uncoupling is an early and reversible trigger of the cardiac dysfunction in a diet-induced mouse model of DCM. Metformin is a first-line antidiabetic dr...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998623/ https://www.ncbi.nlm.nih.gov/pubmed/35408928 http://dx.doi.org/10.3390/ijms23073569 |