Unique Positive Cooperativity Between the β-Arrestin–Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor

Among β-blockers that are clinically prescribed for heart failure, carvedilol is a first-choice agent with unique pharmacological properties. Carvedilol is distinct from other β-blockers in its ability to elicit β-arrestin–biased agonism, which has been suggested to underlie its cardioprotective eff...

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Detalles Bibliográficos
Autores principales: Pani, Biswaranjan, Ahn, Seungkirl, Rambarat, Paula K., Vege, Shashank, Kahsai, Alem W., Liu, Andrew, Valan, Bruno N., Staus, Dean P., Costa, Tommaso, Lefkowitz, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998675/
https://www.ncbi.nlm.nih.gov/pubmed/34580163
http://dx.doi.org/10.1124/molpharm.121.000363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998675/
https://www.ncbi.nlm.nih.gov/pubmed/34580163
http://dx.doi.org/10.1124/molpharm.121.000363

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